Clinical Knowledge Question Results

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Question: Checkpoint inhibitor immunotherapy is in widespread use for melanoma and non-small cell lung cancer, among many other cancer types. Neurologic adverse effects related to the use of a checkpoint inhibitor include all of the following except:

20% of
Medical Professionals
Chose A


16% of
Medical Professionals
Chose B


47% of
Medical Professionals
Chose C

18% of
Medical Professionals
Chose D

Answer: C. Despite important clinical benefits, checkpoint inhibition is associated with a unique spectrum of side effects termed immune-related adverse events (irAEs) affecting multiple organ systems (including neurologic, endocrine, dermatologic, gastrointestinal, and pulmonary). The spectrum of potential neurologic irAEs includes autoimmune encephalitis, aseptic meningitis, cranial neuropathies, peripheral sensory and motor neuropathies, transverse myelitis, and myasthenia gravis. Parkinson disease has not been associated with checkpoint inhibition.

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