Clinical Knowledge Question Results

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Question: Which of the following treatments may be appropriate for treatment of knee osteoarthritis:

10% of
Medical Professionals
Chose A


41% of
Medical Professionals
Chose B


26% of
Medical Professionals
Chose C

23% of
Medical Professionals
Chose D

Answer: B. Topical NSAIDs are an appropriate first-line therapy for mild knee osteoarthritis (OA); at least 50 percent improvement in pain was found in about 60 percent of patients in a systematic review. Intraarticular hyaluronic acid lacks robust evidence of benefit, is expensive, and can cause pain flare-ups. Acetaminophen has a non-clinically significant effect on pain and can cause harm at higher doses, which may be unknowingly ingested as the medication is combined with other drugs in various over-the-counter formulations. Tramadol, a weak opioid agonist, has been suggested by some treatment guidelines but has the potential to cause harm with long-term use and we avoid opioids for the management of knee OA.

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